If you have diabetes and shooting, burning, pins and needles pain in your feet or hands, you could have painful diabetic peripheral neuropathy—also known as diabetic nerve pain (DNP). It is a common complication of diabetes. The most common cause is poorly controlled blood sugar over time. High blood sugar (glucose) can injure nerve fibers throughout your body, but diabetic neuropathy most often damages nerves in your legs and feet.
Diabetic nerve pain can take years to develop. In the early stages, you may have no signs at all, and then only start to feel a tingling or numbness in your feet. As it progresses, you may also feel the pain in your hands and it is often worse at night. This means that your nerves may be damaged for a long time before you experience painful symptoms.
A clinical research study and trial is being conducted to review the efficacy and safety of an investigation drug NYX-2925. Dr. Bhatia’s Neuro Pain Clinic is one of the 35 centers in the United States conducting this clinical trial and is actively recruiting patients who have Type 2 diabetes and have pain associated with diabetic peripheral neuropathy. The trial will last about 6 to 9 weeks, and all eligible patients will receive study related care and study related drugs at no cost.
Who can participate in the study?
- Type 2 Diabetes patients
- Have pain associated with diabetic peripheral neuropathy in the feet and/or legs, and
- Between the age of 18 to 70 years
How is this study evaluated?
Participating patients will be randomly assigned to the study drug. Some patients will receive investigational drug and some will receive a sugar pill called a placebo. To find out, how well the investigational drug works, Dr. Bhatia will assess participant’s pain at different points throughout the study by measuring, for example:
- Pain intensity
- Pain when walking
- Effect of pain on sleep
The trial will also determine the safety of the investigational drug by studying side effects by measuring vital signs, 5-minute electrocardiogram, and clinical lab tests on blood and urine.